Brain Tumors - Neuro Oncology Studies

RIBOCICLIB PLUS EVEROLIMUS FOR RECURRENT HIGH-GRADE GLIOMA
A Phase 0/2 study of ribociclib in combination with everolimus in preoperative Rb-intact recurrent high-grade glioma patients scheduled for resection.
Principal Investigator: Kaith Almefty, MD

https://clinicaltrials.gov/ct2/show/NCT03834740

For questions, please call 480-728-4425.

ABEMACICLIB PLUS LY3214996 FOR RECURRENT GLIOMA
A Phase 0 clinical trial combining Abemaciclib (CDK4/6 inhibitor) and LY3214996 (ERK inhibitor) in recurrent glioblastoma patients scheduled for resection to evaluate central nervous system (CNS) penetration.
Principal Investigator: Kaith Almefty, MD

https://clinicaltrials.gov/ct2/show/NCT04391595

For questions, please call 480-728-4425.

INFIGRATINIB FOR RECURRENT HIGH-GRADE GLIOMA
A Phase 0 study of infigratinib in recurrent high-grade glioma patients with an FGFR gene fusion scheduled for resection to evaluate central nervous system (CNS) penetration with PK triggered expansion cohort.
Principal Investigator: Kaith Almefty, MD

https://clinicaltrials.gov/ct2/show/NCT04424966?term=NCT04424966&draw=2&rank=1

For questions, please call 480-728-4425.

IVY BRAIN TUMOR CENTER DATA AND TISSUE SCREENING PROTOCOL
A registry to collect blood or tumor samples of participants from previous or planned surgeries to determine if the tumors indicate a match to one of the available treatment clinical trial protocols.
Principal Investigator: Kaith Almefty, MD

For questions, please call 480-728-4425.

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